Phenotyping of transgenic and KO mice
(Drug target validation)

The human genome sequence offers a large pool of potential new drug targets to address unmet medical needs and to improve current therapies. One way to test whether a given gene could be a valuable drug target is to generate knock-out or transgenic mice. The thorough analysis of these genetically modified mice reveals whether the phenotype mimics a human disease.

Phenotyping starts with the analysis of blood parameters and a histopathological evaluation of 40 organs. The results on the nature of the affected organs guide subsequent further detailed analyses.

MORPHOME™ packages

Morphome are complete packages used to evaluate the phenotypes of genetically modified mice.

Service number 6600.00: MORPHOME™ Discovery

MORPHOME™ Discovery: a comprehensive histopathological analysis including physiology for both sexes.

Service number 6300.00: MORPHOME™ Junior

MORPHOME™ Junior: focused on developmental defects in prenatal and postnatal specimens, from E9.5 to P6.

Service number 6400.00: MORPHOME™ System

MORPHOME™ System: a comprehensive macroscopic and histopathological analysis of all representative organs of a given functional system.

Blood Parameters

Service number 8000.00: Physiological Parameters:

  • Hematology: blood counts, coagulation
  • Blood Chemistry: metabolites, enzymes, electrolytes (Chemogram up to 20 parameters of your choice)
  • Urine Status: proteins, sediment, test strip